Japanese Encephalitis Virus: An Update on the Potential Antivirals and Vaccines.

ABSTRACT: Japanese encephalitis virus (JEV) is the causal agent behind Japanese encephalitis (JE), a potentially severe brain infection that spreads through mosquito bites. JE is predominant over the Asia-Pacific Region and has the potential to spread globally with a higher rate of morbidity and mortality. Efforts have been made to identify and select various target molecules essential in JEV's progression, but until now, no licensed anti-JEV drug has been available. From a prophylactic point of view, a few licensed JE vaccines are available, but various factors, viz., the high cost and different side effects imposed by them, has narrowed their global use. With an average occurrence of >67,000 cases of JE annually, there is an urgent need to find a suitable antiviral drug to treat patients at the ac

SUBMITTER: Srivastava KS 

PROVIDER: S-EPMC10146181 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature