Lipid Nanoparticles as Promising Carriers for mRNA Vaccines for Viral Lung Infections.

ABSTRACT: In recent years, there has been an increase in deaths due to infectious diseases, most notably in the context of viral respiratory pathogens. Consequently, the focus has shifted in the search for new therapies, with attention being drawn to the use of nanoparticles in mRNA vaccines for targeted delivery to improve the efficacy of these vaccines. Notably, mRNA vaccine technologies denote as a new era in vaccination due to their rapid, potentially inexpensive, and scalable development. Although they do not pose a risk of integration into the genome and are not produced from infectious elements, they do pose challenges, including exposing naked mRNAs to extracellular endonucleases. Therefore, with the development of nanotechnology, we can further improve their efficacy. Nanoparticles, with th

SUBMITTER: Hajiaghapour Asr M 

PROVIDER: S-EPMC10146241 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature