Personality traits as mediators in the association between SIRT1 rs12415800 polymorphism and depressive symptoms among Chinese college students.

ABSTRACT:

Background

Previous research has linked polymorphisms in the SIRT1 gene to depressive symptoms, particularly in Chinese individuals. However, it is not clear how personality traits may contribute to this association.

Methods

To explore the potential mediating effect of personality traits, we utilized a mediation model to examine the relationship between the SIRT1 rs12415800 polymorphism and depressive symptoms in 787 Chinese college students. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale, while personality traits were measured using the Big Five Inventory (BFI).

Results

Our analysis indicated a significant association between the SIRT1 rs12415800 polymorphism and depressive symptoms, with thi

SUBMITTER: Wang C 

PROVIDER: S-EPMC10146254 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature