A Novel Generation of Tailored Antimicrobial Drugs Based on Recombinant Multidomain Proteins.

ABSTRACT: Antibiotic resistance has exponentially increased during the last years. It is necessary to develop new antimicrobial drugs to prevent and treat infectious diseases caused by multidrug- or extensively-drug resistant (MDR/XDR)-bacteria. Host Defense Peptides (HDPs) have a versatile role, acting as antimicrobial peptides and regulators of several innate immunity functions. The results shown by previous studies using synthetic HDPs are only the tip of the iceberg, since the synergistic potential of HDPs and their production as recombinant proteins are fields practically unexplored. The present study aims to move a step forward through the development of a new generation of tailored antimicrobials, using a rational design of recombinant multidomain proteins based on HDPs. This strategy is base

SUBMITTER: Lopez-Cano A 

PROVIDER: S-EPMC10146347 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature