Design, Development, and Evaluation of Treprostinil Embedded Adhesive Transdermal Patch.

ABSTRACT: Clinical application of treprostinil in pulmonary arterial hypertension is hampered by adverse effects caused by its high dosing frequency. The objective of this investigation was to Formulate an adhesive-type transdermal patch of treprostinil and evaluate it both in vitro and in vivo. A 3²-factorial design was utilized to optimize the selected independent variables (X₁: drug amount, X₂: enhancer concentration) on the response variables (Y₁: drug release, Y₂: transdermal flux). The optimized patch was evaluated for various pharmaceutical properties, skin irritation, and pharmacokinetics in rats. Optimization results signify considerable influence (p < 0.0001) of X₁ on both Y₁ and Y₂, as compared

SUBMITTER: Alissa I 

PROVIDER: S-EPMC10146406 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature