Miscibility of Phosphatidylcholines in Bilayers: Effect of Acyl Chain Unsaturation.

ABSTRACT: The miscibility of phospholipids in a hydrated bilayer is an issue of fundamental importance for understanding the organization of biological membranes. Despite research on lipid miscibility, its molecular basis remains poorly understood. In this study, all-atom MD simulations complemented by Langmuir monolayer and DSC experiments have been performed to investigate the molecular organization and properties of lipid bilayers composed of phosphatidylcholines with saturated (palmitoyl, DPPC) and unsaturated (oleoyl, DOPC) acyl chains. The experimental results showed that the DOPC/DPPC bilayers are systems exhibiting a very limited miscibility (strongly positive values of excess free energy of mixing) at temperatures below the DPPC phase transition. The excess free energy of mixing is divided

SUBMITTER: Zak A 

PROVIDER: S-EPMC10146409 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature