Homeostasis at different backgrounds: The roles of overlayed feedback structures in vertebrate photoadaptation.

ABSTRACT: We have studied the resetting behavior of eight basic integral controller motifs with respect to different but constant backgrounds. We found that the controllers split symmetrically into two classes: one class, based on derepression of the compensatory flux, leads to more rapid resetting kinetics as backgrounds increase. The other class, which directly activates the compensatory flux, shows a slowing down in the resetting at increased backgrounds. We found a striking analogy between the resetting kinetics of vertebrate photoreceptors and controllers based on derepression, i.e. vertebrate rod or cone cells show decreased sensitivities and accelerated response kinetics as background illuminations increase. The central molecular model of vertebrate photoadaptation consists of an overlay of t

SUBMITTER: Grini JV 

PROVIDER: S-EPMC10146485 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature