Immune signatures in variant syndromes of primary biliary cholangitis and autoimmune hepatitis.

ABSTRACT:

Background

Variant syndromes of autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) share diagnostic features of both entities, but their immunological underpinnings remain largely unexplored.

Methods

We performed blood profiling of 23 soluble immune markers and immunogenetics in a cohort of 88 patients with autoimmune liver diseases (29 typical AIH, 31 typical PBC and 28 with clinically PBC/AIH variant syndromes). The association with demographical, serological and clinical features was analyzed.

Results

While T and B cell receptor repertoires were highly skewed in variant syndromes compared to healthy controls, these biases were not sufficiently discriminated within the spectrum of autoimmune liver diseases. High circulating checkpoint molecules sCD25,

SUBMITTER: Schultheiß C 

PROVIDER: S-EPMC10146553 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature