Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Y
PROVIDER: S-EPMC10146569 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Zhu Yinxing Y Wang Ruifang R Zou Jiahui J Tian Shan S Yu Luyao L Zhou Yuanbao Y Ran Ying Y Jin Meilin M Chen Huanchun H Zhou Hongbo H
PLoS pathogens 20230413 4
N6-methyladenosine (m6A) modification on viral RNAs has a profound impact on infectivity. m6A is also a highly pervasive modification for influenza viral RNAs. However, its role in virus mRNA splicing is largely unknown. Here, we identify the m6A reader protein YTHDC1 as a host factor that associates with influenza A virus NS1 protein and modulates viral mRNA splicing. YTHDC1 levels are enhanced by IAV infection. We demonstrate that YTHDC1 inhibits NS splicing by binding to an NS 3' splicing sit ...[more]