Impact of Breast Cancer and Germline BRCA Pathogenic Variants on Fertility Preservation in Young Women.

ABSTRACT:

Background

Several studies have suggested that breast cancer (BC) and germline BRCA pathogenic variants (gBRCA PVs) could have a deleterious impact on ovarian reserve. Nevertheless, data are limited and mixed. Our objective was to evaluate the performance of fertility preservation (FP) in terms of the number of collected mature oocytes after ovarian stimulation (OS) in young women carrying a gBRCA PV, associated or not with BC.

Methods

We conducted a retrospective monocentric study at HUB-Hôpital Erasme in Brussels. All women aged between 18 and 41 years diagnosed with invasive non-metastatic BC and/or gBRCA PV carriers who underwent OS for FP or preimplantation genetic testing for monogenic disorder (PGT-M) between November 2012 and October 2021 were included. Three groups

SUBMITTER: Prokurotaite E 

PROVIDER: S-EPMC10146760 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature