Lipidomics Reveals Elevated Plasmalogens in Women with Obesity Who Develop Preeclampsia.

ABSTRACT: Objective: Preeclampsia (PE) is a prevalent pregnancy disorder worldwide with limited preventative treatments available. Obesity triples the risk for PE, yet only 10% of women with obesity develop PE. The factors that distinguish PE from uncomplicated pregnancies in the context of obesity have not been fully established. Methods: We studied a cohort of women with obesity throughout pregnancy to identify lipid mediators and/or biomarkers of PE. Blood samples were collected at each trimester and analyzed by both targeted lipidomics and standard lipid panels. Individual lipid species were compared by PE status at each trimester, as well as by self-identified race (Black vs. White) and fetal sex. Results: Standard lipid panels and clinical measurements revealed few differe

SUBMITTER: Williams IM 

PROVIDER: S-EPMC10147017 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature