Evaluating the effect of metabolic traits on oral and oropharyngeal cancer risk using Mendelian randomization.

ABSTRACT: A recent World Health Organization report states that at least 40% of all cancer cases may be preventable, with smoking, alcohol consumption, and obesity identified as three of the most important modifiable lifestyle factors. Given the significant decline in smoking rates, particularly within developed countries, other potentially modifiable risk factors for head and neck cancer warrant investigation. Obesity and related metabolic disorders such as type 2 diabetes (T2D) and hypertension have been associated with head and neck cancer risk in multiple observational studies. However, adiposity has also been correlated with smoking, with bias, confounding or reverse causality possibly explaining these findings. To overcome the challenges of observational studies, we conducted two-sample Mendel

SUBMITTER: Gormley M 

PROVIDER: S-EPMC10147379 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature