Lifelong regeneration of cerebellar Purkinje cells after induced cell ablation in zebrafish.

ABSTRACT: Zebrafish have an impressive capacity to regenerate neurons in the central nervous system. However, regeneration of the principal neuron of the evolutionary conserved cerebellum, the Purkinje cell (PC), is believed to be limited to developmental stages based on invasive lesions. In contrast, non-invasive cell type-specific ablation by induced apoptosis closely represents a process of neurodegeneration. We demonstrate that the ablated larval PC population entirely recovers in number, quickly reestablishes electrophysiological properties, and properly integrates into circuits to regulate cerebellum-controlled behavior. PC progenitors are present in larvae and adults, and PC ablation in adult cerebelli results in an impressive PC regeneration of different PC subtypes able to restore behaviora

SUBMITTER: Pose-Mendez S 

PROVIDER: S-EPMC10147380 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature