Aldosterone in chronic kidney disease and renal outcomes.

ABSTRACT:

Aims

Randomized controlled trials have demonstrated the efficacy of mineralocorticoid receptor (MR) antagonism in delaying chronic kidney disease (CKD) progression in diabetes; however, they have not investigated the role of aldosterone or whether these beneficial effects could be achieved in individuals without diabetes.

Methods and results

The association between serum aldosterone concentrations and kidney disease progression was investigated among 3680 participants in the Chronic Renal Insufficiency Cohort. The primary outcome was CKD progression [defined as the composite of 50% decline in estimated glomerular filtration rate (eGFR) or end-stage kidney disease, whichever occurred first]. The associations between serum aldosterone and kidney disease outcomes were assessed

SUBMITTER: Verma A 

PROVIDER: S-EPMC10147385 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature