Esophageal mycobiome landscape and interkingdom interactions in esophageal squamous cell carcinoma.

ABSTRACT:

Background

The study purpose was to characterize the mycobiome and its associations with the expression of pathogenic genes in esophageal squamous cell carcinoma (ESCC).

Methods

Patients with primary ESCC were recruited from two central hospitals. We performed internal transcribed spacer 1 (ITS1) ribosomal DNA sequencing analysis. We compared differential fungi and explored the ecology of fungi and the interaction of bacteria and fungi.

Results

The mycobiota diversity was significantly different between tumors and tumor-adjacent samples. We further analysed the differences between the two groups, at the species level, confirming that Rhodotorula toruloides, Malassezia dermatis, Hanseniaspora lachancei, and Spegazzinia tessarthra were excess

SUBMITTER: Rao WQ 

PROVIDER: S-EPMC10147516 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature