Enhanced Ca²⁺-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation.

ABSTRACT:

Background

Small-conductance Ca²⁺-activated K⁺ (SK)-channel inhibitors have antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel antiarrhythmic option. However, the regulation of SK-channels in human atrial cardiomyocytes and its modification in patients with AF are poorly understood and were the object of this study.

Methods

Apamin-sensitive SK-channel current (I_SK) and action potentials were recorded in human right-atrial cardiomyocytes from sinus rhythm control (Ctl) patients or patients with (long-standing persistent) chronic AF (cAF).

Results

I_SK was significantly higher, and apamin caused larger action potential prolongation in cAF- versus Ctl-cardiomyocytes. Sensitivity ana

SUBMITTER: Heijman J 

PROVIDER: S-EPMC10147588 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature