Cancer-specific tissue-resident memory T-cells express ZNF683 in colorectal cancer.

ABSTRACT:

Background

Tissue-resident memory T (Trm) cells are associated with cytotoxicity not only in viral infection and autoimmune disease pathologies but also in many cancers. Tumour-infiltrating CD103⁺ Trm cells predominantly comprise CD8 T cells that express cytotoxic activation and immune checkpoint molecules called exhausted markers. This study aimed to investigate the role of Trm in colorectal cancer (CRC) and characterise the cancer-specific Trm.

Methods

Immunochemical staining with anti-CD8 and anti-CD103 antibodies for resected CRC tissues was used to identify the tumour-infiltrating Trm cells. The Kaplan-Meier estimator was used to evaluate the prognostic significance. Cells immune to CRC were targeted for single-cell RNA-seq analysis to characterise cancer-spe

SUBMITTER: Kitakaze M 

PROVIDER: S-EPMC10147592 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature