Annexins A2 and A5 are potential early biomarkers of hepatocarcinogenesis.

ABSTRACT: Hepatocellular carcinoma (HCC) is a highly lethal liver cancer with late diagnosis; therefore, the identification of new early biomarkers could help reduce mortality. We determine the tissue and plasma status of five annexins during hepatocarcinogenesis by diethylnitrosamine-induced cirrhosis-HCC. We found that Anxa5 was the earliest upregulated gene at week 12 after HCC initiation, while Anxa1 and Anxa2 were upregulated in advanced HCC stages (weeks 18 and 22). Furthermore, the protein level of Annexin A1, A2, A5 and A10 was increased from the early stages. Immunofluorescence and subcellular fractionation revealed Annexin A1, A2, and A5 in the cytoplasm and nuclei of tumor cells. Notably, increased plasma levels of Annexin A5 significantly (r² = 0.8203) correlated with Annexin

SUBMITTER: Herrera-Lopez EE 

PROVIDER: S-EPMC10147597 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature