The Newfoundland and Labrador mosaic founder population descends from an Irish and British diaspora from 300 years ago.

ABSTRACT: The founder population of Newfoundland and Labrador (NL) is a unique genetic resource, in part due to its geographic and cultural isolation, where historical records describe a migration of European settlers, primarily from Ireland and England, to NL in the 18th and 19th centuries. Whilst its historical isolation, and increased prevalence of certain monogenic disorders are well appreciated, details of the fine-scale genetic structure and ancestry of the population are lacking. Understanding the genetic origins and background of functional, disease causing, genetic variants would aid genetic mapping efforts in the Province. Here, we leverage dense genome-wide SNP data on 1,807 NL individuals to reveal fine-scale genetic structure in NL that is clustered around coastal communities and correl

SUBMITTER: Gilbert E 

PROVIDER: S-EPMC10147672 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature