Long-term risks of invasive cervical cancer following HPV infection: follow-up of two screening cohorts in Manchester.

ABSTRACT:

Background

Long-term follow-up of large cohorts is needed to determine the effects of HPV and screening on CIN3 (grade 3 cervical intraepithelial neoplasia) and ICC (invasive cervical cancer).

Methods

Women were recruited when attending for routine cervical screening in Greater Manchester, UK: 1987-93 for the Manchester Cohort (MC: 47,625 women) and 2001-03 for the ARTISTIC Cohort (AC: 24,496 women). Both were followed through national registration for cancer incidence and mortality to 2020.

Results

Risk patterns following HPV infection differed for CIN3 and ICC. Risk of ICC in the MC rises for 30 years following a single positive HPV test, reaching 2.5% (95% CI: 1.3-4.5%). A similar pattern was seen in the AC, but the risks of cancer were approximately halved. CIN3 w

SUBMITTER: Gilham C 

PROVIDER: S-EPMC10147679 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature