Discordance between PAM50 intrinsic subtyping and immunohistochemistry in South African women with breast cancer.

ABSTRACT:

Purpose

Breast cancer is a heterogeneous disease with different gene expression profiles, treatment options and outcomes. In South Africa, tumors are classified using immunohistochemistry. In high-income countries multiparameter genomic assays are being utilized with implications for tumor classification and treatment.

Methods

In a cohort of 378 breast cancer patients from the SABCHO study, we investigated the concordance between tumor samples classified by IHC and the PAM50 gene assay.

Results

IHC classified patients as ER-positive (77.5%), PR-positive (70.6%), and HER2-positive (32.3%). These results, together with Ki67, were used as surrogates for intrinsic subtyping, and showed 6.9% IHC-A-clinical, 72.7% IHC-B-clinical, 5.3% IHC-HER2-clinical and 15.1% triple nega

SUBMITTER: Dix-Peek T 

PROVIDER: S-EPMC10147771 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature