Effects of transdermal versus oral hormone replacement therapy in postmenopause: a systematic review.

ABSTRACT:

Purpose

To summarize available evidence comparing the transdermal and the oral administration routes of hormone replacement therapy (HRT) in postmenopausal women.

Methods

We performed a systematic review of the literature on multiple databases between January 1990 and December 2021. We included randomized controlled trials and observational studies comparing the transdermal and oral administration routes of estrogens for HRT in postmenopausal women regarding at least one of the outcomes of interest: cardiovascular risk, venous thromboembolism (VTE), lipid metabolism, carbohydrate metabolism, bone mineral density (BMD), and risk of pre-malignant and malignant endometrial lesions, or breast cancer.

Results

The systematic literature search identified a total of 1369 manu

SUBMITTER: Goldstajn MS 

PROVIDER: S-EPMC10147786 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature