Public perceptions and expectations: Disentangling the hope and hype of organoid research

ABSTRACT: Summary Organoid technologies are rapidly advancing and hold great potential and hope for disease modeling and clinical translational research. Still, they raise a number of complex, ethical questions regarding their current and future use. Patient and public involvement is important in building public trust and helping to secure responsible conduct and valued innovations; nevertheless, research into patient and public perspectives on organoid technologies remains scarce. We report on a first public dialogue on organoid technologies through three cross-country deliberative workshops with a diverse group of stakeholders to identify their perceptions and concerns. Participants generally support organoid technologies on the condition that responsible governance, ethical oversight, and sound informed consent procedures are in place. Yet, a broad set of potential concerns are identified, primarily concerning commercialization, healthcare access, and cerebral organoids. Participants’ insights and recommendations can help inform researchers and ethics and policy bodies toward supporting responsible and ethical organoid approaches. Highlights • Three cross-country deliberations on public perceptions of organoid research• Public support but responsible governance and sound consent procedures required• Concerns include commercialization, healthcare access, and cerebral organoids• Provision of co-produced recommendations to support responsible organoid research In this article, Ravn and colleagues report on a first public dialogue on organoid technologies with a diverse group of stakeholders to identify their perceptions and concerns. Participants generally support organoid research on the condition that responsible governance, ethical oversight, and sound informed consent procedures are in place. Yet, a number of concerns are expressed, primarily concerning commercialization, healthcare access, and cerebral organoids.

SUBMITTER: Ravn T 

PROVIDER: S-EPMC10147824 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature