Non-trivial dynamics in a model of glial membrane voltage driven by open potassium pores.

ABSTRACT: Despite the molecular evidence that a nearly linear steady-state current-voltage relationship in mammalian astrocytes reflects a total current resulting from more than one differentially regulated K⁺ conductance, detailed ordinary differential equation (ODE) models of membrane voltage V_m are still lacking. Various experimental results reporting altered rectification of the major Kir currents in glia, dominated by Kir4.1, have motivated us to develop a detailed model of V_m dynamics incorporating the weaker potassium K2P-TREK1 current in addition to Kir4.1, and study the stability of the resting state V_r. The main question is whether, with the loss of monotonicity in glial I-V curve resulting from altered Kir rectification, the nominal resting stat

SUBMITTER: Janjic P 

PROVIDER: S-EPMC10147837 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature