The stress-free state of human erythrocytes: Data-driven inference of a transferable RBC model.

ABSTRACT: The stress-free state (SFS) of red blood cells (RBCs) is a fundamental reference configuration for the calibration of computational models, yet it remains unknown. Current experimental methods cannot measure the SFS of cells without affecting their mechanical properties, whereas computational postulates are the subject of controversial discussions. Here, we introduce data-driven estimates of the SFS shape and the visco-elastic properties of RBCs. We employ data from single-cell experiments that include measurements of the equilibrium shape of stretched cells and relaxation times of initially stretched RBCs. A hierarchical Bayesian model accounts for these experimental and data heterogeneities. We quantify, for the first time, the SFS of RBCs and use it to introduce a transferable RBC (t-RB

SUBMITTER: Amoudruz L 

PROVIDER: S-EPMC10147838 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature