Multicenter prospective study showing a high gastrointestinal symptom burden in cystic fibrosis.

ABSTRACT:

Background and aims

People with cystic fibrosis (PwCF) suffer from gastrointestinal (GI) symptoms affecting their quality of life (QOL). Despite the relevance of GI symptoms to the overall health of PwCF, a paucity of studies only have comprehensively assessed the prevalence, severity and QOL of GI symptoms in both children and adults with Cystic Fibrosis (CF).

Methods

Eligible participants ≥2 years of age across 26 US CF centers were followed for 4 weeks. Three validated GI electronic patient-reported outcome measures (ePROMs) with a recall period of 2 weeks and a stool-specific questionnaire were administered weekly over four weeks. Total and domain scores of ePROMs were evaluated overall and in subgroups using linear mixed-effect models.

Results

Of 402 enrolled, 58

SUBMITTER: Moshiree B 

PROVIDER: S-EPMC10147845 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature