In vitro evaluation of (S)-2-amino-3-[3-(2-¹⁸F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (¹⁸F-FIMP) as a positron emission tomography probe for imaging amino acid transporters.

ABSTRACT:

Background

(S)-2-amino-3-[3-(2-¹⁸F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (¹⁸F-FIMP) as a promising PET probe for imaging the tumor-specific L-type amino acid transporter (LAT) 1. Our previous study revealed that ¹⁸F-FIMP had a higher affinity for LAT1 than for LAT2 abundantly expressed even in normal cells. ¹⁸F-FIMP showed high accumulation in LAT1-positive tumor tissues and low accumulation in inflamed lesions in tumor-bearing mice. However, the affinity of ¹⁸F-FIMP for other amino acid transporters was not determined yet. Here, we aimed to determine whether ¹⁸F-FIMP has affinity for other tumor-related amino acid transporters, such as sodium- and chloride-dependent neutral and basic amino acid transpor

SUBMITTER: Nozaki S 

PROVIDER: S-EPMC10147893 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature