Sequential targeting of PARP with carboplatin inhibits primary tumour growth and distant metastasis in triple-negative breast cancer.

ABSTRACT:

Background

Patients with triple-negative breast cancer (TNBC) develop early recurrence. While PARP inhibitors (PARPi) have demonstrated potential in BRCA1/2-mutant (BRCA^MUT) TNBC, durable responses will likely be achieved if PARPi are used in combination. It is plausible that sequential administration of a potent PARPi like talazoparib in combination with carboplatin can enhance primary tumour and metastasis inhibition in BRCA^MUT and BRCA1/2 wild-type (BRCA^WT) TNBCs, and decrease toxicity.

Methods

We evaluated the impact of the concurrent combination of talazoparib and carboplatin on cell survival in 13 TNBC cell lines. We compared the concurrent and sequential combination upon fork replication, migration and invasion. We also used three orth

SUBMITTER: Beniey M 

PROVIDER: S-EPMC10147920 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature