Macrophages mediate psoriasis via Mincle-dependent mechanism in mice.

ABSTRACT: Psoriasis is currently considered to be an immune and inflammatory disease characterized by massive immune cells infiltration including macrophages. It has been reported that macrophage-inducible C-type lectin (Mincle) is essential to maintain the pro-inflammatory phenotype of M1 macrophages, however, its role and mechanisms in psoriasis remain largely unknown. A model of psoriasis was induced in mice by a daily topical application of imiquimod for 7 days. Role and mechanisms of Mincle in macrophage-mediated psoriasis were investigated in clodronate liposomes induced macrophage depletion mice followed by adoptively transferring with Mincle-expressing or -knockout (KO) macrophages, and in macrophage specific Mincle knockout mice (Mincle^loxp/loxp/Lyz2-cre^+/+). Finally,

SUBMITTER: Tan RZ 

PROVIDER: S-EPMC10147944 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature