Genetic polymorphism between the Sorani and Hawrami kurdish populations and COVID-19 outcome.

ABSTRACT:

Background

Coronavirus Disease 2019 (COVID-19) is a global pandemic, and mortality and clinical consequences vary across countries. One of the factors influencing COVID-19 outcomes is genetic polymorphism. Two Kurdish populations, Sorani and Hawrami, live in the Sulaimani province of the Kurdistan Region of Iraq. It seems Hawrami had a milder COVID-19 outcome. According to previous research conducted on various ethnic groups across the globe, single nucleotide polymorphisms (SNPs) in the interferon-induced transmembrane protein 3 (IFITM3) and interluken-6 (IL6) genes were associated with the severity of COVID-19 in those populations.

Methods and results

We hypothesized that Hawrami may have protective SNPs. So, in this study, we used DNA sequencing to genotype three IFITM3 S

SUBMITTER: Rashid PMA 

PROVIDER: S-EPMC10148000 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature