Differential changes in cyclic adenosine 3'-5' monophosphate (cAMP) effectors and major Ca²⁺ handling proteins during diabetic cardiomyopathy.

ABSTRACT: Diabetic cardiomyopathy (DCM) is associated with differential and time-specific regulation of β-adrenergic receptors and cardiac cyclic nucleotide phosphodiesterases with consequences for total cyclic adenosine 3'-5' monophosphate (cAMP) levels. We aimed to investigate whether these changes are associated with downstream impairments in cAMP and Ca²⁺ signalling in a type 1 diabetes (T1D)-induced DCM model. T1D was induced in adult male rats by streptozotocin (65 mg/kg) injection. DCM was assessed by cardiac structural and molecular remodelling. We delineated sequential changes affecting the exchange protein (Epac1/2), cAMP-dependent protein kinase A (PKA) and Ca²⁺ /Calmodulin-dependent kinase II (CaMKII) at 4, 8 and 12 weeks following diabetes, by real-time quantitativ

SUBMITTER: Chaoul V 

PROVIDER: S-EPMC10148055 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature