The Circ_35953 induced by the NF-κB mediated the septic AKI via targeting miR-7219-5p/HOOK3 and IGFBP7 axis.
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ABSTRACT:
SUBMITTER: Feng Y
PROVIDER: S-EPMC10148060 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
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The Circ_35953 induced by the NF-κB mediated the septic AKI via targeting miR-7219-5p/HOOK3 and IGFBP7 axis.
Feng Yuqing Y Liu Bohao B Chen Jinwen J Li Huiling H Zhang Dongshan D
Journal of cellular and molecular medicine 20230328 9
A few studies suggested that CircRNAs were involved in the development of septic AKI. However，the role and regulation mechanism of CircRNA_35953 in septic AKI remains unclear. Here, we found that Circ_35953 was induced by LPS via activation of NF-κB signal in BUMPT cells. Functionally, Circ_35953 mediated the LPS induced the apoptosis in BUMPT cells. Moreover, we demonstrated that Circ_35953 sponged miR-7219-5p to upregulate the expression of HOOK3 and IGFBP7. Finally, we verified that knock dow ...[more]
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