The Role of Apoptotic Genes and Protein-Protein Interactions in Triple-negative Breast Cancer.

ABSTRACT:

Background/aim

Compared to other breast cancer types, triple-negative breast cancer (TNBC) has historically had few treatment alternatives. Therefore, exploring and pinpointing potentially implicated genes could be used for treating and managing TNBC. By doing this, we will provide essential data to comprehend how the genes are involved in the apoptotic pathways of the cancer cells to identify potential therapeutic targets. Analysis of a single genetic alteration may not reveal the pathogenicity driving TNBC due to the high genomic complexity and heterogeneity of TNBC. Therefore, searching through a large variety of gene interactions enabled the identification of molecular therapeutic genes.

Materials and methods

This study used integrated bioinformatics methods such as UALC

SUBMITTER: Adinew GM 

PROVIDER: S-EPMC10148064 | biostudies-literature | 2023 May-Jun

REPOSITORIES: biostudies-literature