Altered gray matter volumes and plasma IL-6 level in major depressive disorder patients with suicidal ideation.

ABSTRACT:

Backgrounds

Suicidal ideation (SI) is one of the most serious consequences of major depressive disorder (MDD). Understanding the unique mechanism of MDD with SI (MDD + S) is crucial for treatment development. While abundant research has studied MDD, past studies have not reached a consensus on the mechanism of MDD + S. The study aimed to investigate the abnormalities of the gray matter volumes (GMVs) and plasma IL-6 level in MDD + S to further reveal the mechanism of MDD + S.

Methods

We tested the plasma IL-6 level using Luminex multifactor assays and collected the Structural Magnetic Resonance Imaging (SMRI) data from 34 healthy controls (HCs), 36 MDD patients without SI (MDD - S) and 34 MDD + S patients. We performed a partial correlation between the GMVs of the brain regi

SUBMITTER: Guo Y 

PROVIDER: S-EPMC10148078 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature