Alteration in ventral tegmental area and default mode network interplay and prediction of coma recovery in patients with sTBI.

ABSTRACT:

Purpose

To investigate the role of VTA and DMN in modulating human consciousness in patient with sTBI.

Methods

We mapped an atlas of VTA in the brainstem and a total of 19 region of interests in the ventral and dorsal DMN onto functional magnetic resonance imaging in 28 patients with sTBI and 28 healthy controls. We assessed the functional connectivity alteration in subcortical VTA and cortical DMN nodes in patients of coma. We evaluated the spatially distribution of FC alteration in VTA and DMN nodes after sTBI and evaluated their predictive value for coma recovery.

Results

There was a decrease in FC between VTA and DMN in patients compared to controls. After decomposition, the FC between VTA and 10 DMN nodes were decreased whereas the FC within 2 DMN nodes were incr

SUBMITTER: Xu C 

PROVIDER: S-EPMC10148103 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature