Modulators of diabetic neuropathy and inflammation from Saponaria officinalis: Isolation of active phytochemicals and potential mechanisms of action.

ABSTRACT:

Background and aim

Natural metabolites are rich in neuroactive and anti-inflammatory phytochemicals. Soapwort or Saponaria officinalis (Sap) has been utilized for its immunomodulatory and ant-rheumatic properties. Thus, the aim is to exploit Sap phytochemically and to investigate Sap isolated active phytochemicals effect to modulate diabetic neuropathy and inflammation, and their possible mechanisms of action.

Experimental procedure

Bio-guided chromatographic fractionation and phytochemical isolation of the most abundant Sap phytochemicals utilizing RP-HPLC, ¹³C, and ¹H NMR, in-vivo models of diabetes, diabetic neuropathy, and inflammation were used. Glucometers, HbA1c micro-columns, in-vivo hind-paw edema, tail-flick, hot plate, and Von-F

SUBMITTER: Raafat K 

PROVIDER: S-EPMC10148123 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature