Interplay of lipid head group and packing defects in driving amyloid-beta-mediated myelin-like model membrane deformation.

ABSTRACT: Accumulating evidence suggests that amyloid plaque-associated myelin lipid loss as a result of elevated amyloid burden might also contribute to Alzheimer's disease. The amyloid fibrils are closely associated with lipids under physiological conditions; however, the progression of membrane remodeling events leading to lipid-fibril assembly remains unknown. Here we first reconstitute the interaction of amyloid Beta 40 (Aβ-40) with myelin-like model membrane and show that the binding of Aβ-40 induces extensive tubulation. To look into the mechanism of membrane tubulation, we chose a set of membrane conditions varying in lipid packing density and net charge that allows us to dissect the contribution of lipid specificity of Aβ-40 binding, aggregation kinetics, and subsequent changes in membrane

SUBMITTER: Tiwari A 

PROVIDER: S-EPMC10148160 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature