Associations of socioeconomic disparities with buccal DNA-methylation measures of biological aging.

ABSTRACT:

Background

Individuals who are socioeconomically disadvantaged are at increased risk for aging-related diseases and perform less well on tests of cognitive function. The weathering hypothesis proposes that these disparities in physical and cognitive health arise from an acceleration of biological processes of aging. Theories of how life adversity is biologically embedded identify epigenetic alterations, including DNA methylation (DNAm), as a mechanistic interface between the environment and health. Consistent with the weathering hypothesis and theories of biological embedding, recently developed DNAm algorithms have revealed profiles reflective of more advanced aging and lower cognitive function among socioeconomically-at-risk groups. These DNAm algorithms were developed using bloo

SUBMITTER: Raffington L 

PROVIDER: S-EPMC10148429 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature