Cross-talks between gut microbiota and tobacco smoking: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Considerable evidence has been reported that tobacco use could cause alterations in gut microbiota composition. The microbiota-gut-brain axis also in turn hinted at a possible contribution of the gut microbiota to smoking. However, population-level studies with a higher evidence level for causality are lacking.

Methods

This study utilized the summary-level data of respective genome-wide association study (GWAS) for 211 gut microbial taxa and five smoking phenotypes to reveal the causal association between the gut microbiota and tobacco smoking. Two-sample bidirectional Mendelian randomization (MR) design was deployed and comprehensively sensitive analyses were followed to validate the robustness of results. We further performed multivariable MR to evaluate the eff

SUBMITTER: Fan J 

PROVIDER: S-EPMC10148467 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature