The effect of azithromycin on sputum inflammatory markers in bronchiectasis.

ABSTRACT:

Background

Long term macrolide treatment has been found beneficial in bronchiectasis (BE) -pathogical bronchial dilatation- possibly due to a combined anti-bacterial and immunomodulatory effect. The exact mechanism of inflammatory response is unknown. Here, we investigated the effect of maintenance macrolide treatment on the inflammatory response in BE. In addition, we assessed the inflammatory profile in BE in relation to disease severity.

Methods

During the BAT randomized controlled trial (investigating the effect of 1 year of azithromycin (AZM) in 83 BE patients), data on BE severity, lung function and sputum microbiology was collected. For the current study, a wide range of inflammatory markers were analysed in 3- monthly sputum samples in all participants.

Results

SUBMITTER: Terpstra LC 

PROVIDER: S-EPMC10148509 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature