Meloxicam inhibits STING phosphorylation and alleviates intracellular DNA-mediated autoimmune responses.

ABSTRACT:

Background

Cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is critical for cytosolic DNA-sensing and the subsequent immune responses. The inappropriate activation of this pathway leads to DNA-induced autoimmune response. Understanding the precise regulation of cGAS-STING pathway is important for developing therapeutics to treat several autoimmune diseases caused by self-DNA.

Results

We report that Meloxicam (MXC) inhibits intracellular DNA-, but not RNA-induced immune responses. We find that MXC inhibits the phosphorylation of STING by examining in different cells with various DNA stimulations. We further find that MXC significantly dampens the expression levels of interferon-stimulated genes (ISGs) by using DNA 3' repair exonuclease 1 (TREX1)-d

SUBMITTER: Yu Y 

PROVIDER: S-EPMC10148517 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature