Gut taste receptor type 1 member 3 is an intrinsic regulator of Western diet-induced intestinal inflammation.

ABSTRACT:

Background

Long-term intake of a Western diet (WD), characterized by a high-fat content and sugary drinks, is hypothesized to contribute to the development of inflammatory bowel disease (IBD). Despite the identified clinical association, the molecular mechanisms by which dietary changes contribute to IBD development remain unknown. Therefore, we examined the influence of long-term intake of a WD on intestinal inflammation and the mechanisms by which WD intake affects IBD development.

Methods

Mice fed normal diet or WD for 10 weeks, and bowel inflammation was evaluated through pathohistological and infiltrated inflammatory cell assessments. To understand the role of intestinal taste receptor type 1 member 3 (TAS1R3) in WD-induced intestinal inflammation, cultured enteroendocr

SUBMITTER: Shon WJ 

PROVIDER: S-EPMC10148556 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature