Perturbation of the host cell Ca²⁺ homeostasis and ER-mitochondria contact sites by the SARS-CoV-2 structural proteins E and M.

ABSTRACT: Coronavirus disease (COVID-19) is a contagious respiratory disease caused by the SARS-CoV-2 virus. The clinical phenotypes are variable, ranging from spontaneous recovery to serious illness and death. On March 2020, a global COVID-19 pandemic was declared by the World Health Organization (WHO). As of February 2023, almost 670 million cases and 6,8 million deaths have been confirmed worldwide. Coronaviruses, including SARS-CoV-2, contain a single-stranded RNA genome enclosed in a viral capsid consisting of four structural proteins: the nucleocapsid (N) protein, in the ribonucleoprotein core, the spike (S) protein, the envelope (E) protein, and the membrane (M) protein, embedded in the surface envelope. In particular, the E protein is a poorly characterized viroporin with high identity among

SUBMITTER: Poggio E 

PROVIDER: S-EPMC10148623 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature