Retrospective examination of pseudoprogression in IDH mutant gliomas.

ABSTRACT:

Background

Tumor surveillance of isocitrate dehydrogenase (IDH) mutant gliomas is accomplished via serial contrast MRI. When new contrast enhancement (CEnew) is detected during postsurgical surveillance, clinicians must assess whether CEnew indicates pseudoprogression (PsP) or tumor progression (TP). PsP has been better studied in IDH wild-type glioblastoma but has not been well characterized in IDH mutant gliomas. We conducted a retrospective study evaluating the incidence, predictors, natural history, and survival of PsP patients in a large cohort of IDH mutant glioma patients treated at a single institution.

Methods

We identified 587 IDH mutant glioma patients treated at UCLA. We directly inspected MRI images and radiology reports to ide

SUBMITTER: Wetzel EA 

PROVIDER: S-EPMC10148681 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature