Isoflavone consumption reduces inflammation through modulation of phenylalanine and lipid metabolism.

ABSTRACT:

Introduction

Phytoestrogens found in soy, fruits, peanuts, and other legumes, have been identified as metabolites capable of providing beneficial effects in multiple pathological conditions due to their ability to mimic endogenous estrogen. Interestingly, the health-promoting effects of some phytoestrogens, such as isoflavones, are dependent on the presence of specific gut bacteria. Specifically, gut bacteria can metabolize isoflavones into equol, which has a higher affinity for endogenous estrogen receptors compared to dietary isoflavones. We have previously shown that patients with multiple sclerosis (MS), a neuroinflammatory disease, lack gut bacteria that are able to metabolize phytoestrogen. Further, we have validated the importance of both isoflavones and phytoestrogen-metabo

SUBMITTER: Shrode RL 

PROVIDER: S-EPMC10148689 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature