Exploration of natural compounds against the human mpox virus DNA-dependent RNA polymerase in silico.

ABSTRACT:

Background

Last year, the human monkeypox virus (hMPXV) emerged as an alarming threat to the community, with a detectable outbreak outside the African continent for the first time. According to The American Centers for Disease Control and Prevention (CDC), the virus is reported globally, with 86,746 confirmed cases (until April 08, 2023). DNA-dependent RNA polymerase (DdRp) is an essential protein for viral replication; hence it is a promising drug target for developing antiviral drugs against DNA viruses. Therefore, this study was conducted to search for natural compounds that could provide scaffolds for RNA polymerase inhibitors.

Methods

In this study, the DdRp structure of hMPXV was modeled and used to screen the natural compounds database (COCONUT). The virtual screening

SUBMITTER: Abduljalil JM 

PROVIDER: S-EPMC10148721 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature