Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis.

ABSTRACT: Non-opioid targets are needed for addressing osteoarthritis pain, which is mechanical in nature and associated with daily activities such as walking and climbing stairs. Piezo2 has been implicated in the development of mechanical pain, but the mechanisms by which this occurs remain poorly understood, including the role of nociceptors. Here we show that nociceptor-specific Piezo2 conditional knock-out mice were protected from mechanical sensitization associated with inflammatory joint pain in female mice, joint pain associated with osteoarthritis in male mice, as well as both knee swelling and joint pain associated with repeated intra-articular injection of nerve growth factor in male mice. Single cell RNA sequencing of mouse lumbar dorsal root ganglia and in situ hybridization of mouse and

SUBMITTER: Obeidat AM 

PROVIDER: S-EPMC10148822 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature