Cortical thinning in relation to impaired insight into illness in patients with treatment resistant schizophrenia.

ABSTRACT: Impaired insight into illness is a common element of schizophrenia that contributes to treatment nonadherence and negative clinical outcomes. Previous studies suggest that impaired insight may arise from brain abnormalities. However, interpretations of these findings are limited due to small sample sizes and inclusion of patients with a narrow range of illness severity and insight deficits. In a large sample of patients with schizophrenia, the majority of which were designated as treatment-resistant, we investigated the associations between impaired insight and cortical thickness and subcortical volumes. A total of 94 adult participants with a schizophrenia spectrum disorder were included. Fifty-six patients (60%) had treatment-resistant schizophrenia. The core domains of insight were asse

SUBMITTER: Kim J 

PROVIDER: S-EPMC10148890 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature