Methylation of nonessential genes in cutaneous melanoma - Rule Out hypothesis.

ABSTRACT: Differential methylation plays an important role in melanoma development and is associated with survival, progression and response to treatment. However, the mechanisms by which methylation promotes melanoma development are poorly understood. The traditional explanation of selective advantage provided by differential methylation postulates that hypermethylation of regulatory 5'-cytosine-phosphate-guanine-3' dinucleotides (CpGs) downregulates the expression of tumor suppressor genes and therefore promotes tumorigenesis. We believe that other (not necessarily alternative) explanations of the selective advantages of methylation are also possible. Here, we hypothesize that melanoma cells use methylation to shut down transcription of nonessential genes - those not required for cell survival and

SUBMITTER: Gorlov IP 

PROVIDER: S-EPMC10148896 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature