The effects of exercise and diet on oxidative stress and telomere length in breast cancer survivors.

ABSTRACT:

Purpose

Cancer and its treatments accelerate biological aging. This analysis tested the hypothesis that exercise and diet reduce oxidative stress and prevent telomere shortening in breast cancer survivors.

Methods

In a 2 × 2 factorial design, 342 breast cancer survivors who were insufficiently physically active and had overweight or obesity at enrollment were randomized to one of four treatment groups for 52 weeks: control, exercise alone, diet alone, or exercise plus diet. The endpoints of this analysis were the change from baseline to week 52 in 8-iso-prostaglandin F_2α (8-iso-PGF_2α) and lymphocyte telomere length.

Results

Baseline telomere length was shorter than age-adjusted normative values (median difference: - 1.8 kilobases; 95% CI - 2.4, -

SUBMITTER: Brown JC 

PROVIDER: S-EPMC10148914 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature